Sports Info Solutions’ Dominic Asta and Harris Yudin compiled their consensus top 50 NCAA Division I prospect rankings for the 2019 MLB draft class. Links direct to scouting reports for each of the 50 prospects. Also be sure to check out the SIS Mock Draft.
| Ranking | Name | Position | School |
| 1 | Adley Rutschman | C | Oregon State |
| 2 | Andrew Vaughn | 1B | California |
| 3 | Hunter Bishop | OF | Arizona State |
| 4 | Nick Lodolo | LHP | TCU |
| 5 | JJ Bleday | OF | Vanderbilt |
| 6 | Josh Jung | 3B | Texas Tech |
| 7 | Bryson Stott | SS | UNLV |
| 8 | Alek Manoah | RHP | West Virginia |
| 9 | Kameron Misner | OF | Missouri |
| 10 | Shea Langeliers | C | Baylor |
| 11 | Logan Davidson | SS | Clemson |
| 12 | George Kirby | RHP | Elon |
| 13 | Zack Thompson | LHP | Kentucky |
| 14 | Michael Busch | 1B/OF | North Carolina |
| 15 | Braden Shewmake | SS/3B | Texas A&M |
| 16 | Will Wilson | SS | NC State |
| 17 | Seth Johnson | RHP | Campbell |
| 18 | Logan Wyatt | 1B | Louisville |
| 19 | Kody Hoese | 3B | Tulane |
| 20 | Ryne Nelson | RHP | Oregon |
| 21 | Matt Canterino | RHP | Rice |
| 22 | Matt Wallner | OF | Southern Miss |
| 23 | Isaiah Campbell | RHP | Arkansas |
| 24 | John Doxakis | LHP | Texas A&M |
| 25 | Greg Jones | SS | UNC Wilmington |
| 26 | Michael Toglia | 1B/OF | UCLA |
| 27 | Josh Smith | SS | LSU |
| 28 | Nick Quintana | 3B | Arizona |
| 29 | Chase Strumpf | 2B/OF | UCLA |
| 30 | Noah Song | RHP | Navy |
| 31 | Drew Mendoza | 3B | Florida State |
| 32 | Matt Cronin | LHP | Arkansas |
| 33 | Brady McConnell | SS | Florida |
| 34 | Cameron Cannon | 2B/3B | Arizona |
| 35 | Drey Jameson | RHP | Ball State |
| 36 | Ethan Small | LHP | Mississippi State |
| 37 | Dominic Fletcher | OF | Arkansas |
| 38 | Kyle Stowers | OF | Stanford |
| 39 | Ryan Garcia | RHP | UCLA |
| 40 | Bryant Packard | OF | East Carolina |
| 41 | Ryan Zeferjahn | RHP | Kansas |
| 42 | Will Holland | SS | Auburn |
| 43 | Aaron Schunk | 3B/RHP | Georgia |
| 44 | Zack Hess | RHP | LSU |
| 45 | Tommy Henry | LHP | Michigan |
| 46 | Will Robertson | OF | Creighton |
| 47 | Erik Miller | LHP | Stanford |
| 48 | Zach Watson | OF | LSU |
| 49 | Spencer Brickhouse | 1B | East Carolina |
| 50 | Tyler Baum | RHP | North Carolina |